Developmental Disorders of the Lymphatics

An information blog for disorders of the lymphatics. For all articles, please click on "Archives" - Due to spammers, I will no longer allow comments, sorry.

Saturday, October 27, 2007

Lymphangiomatosis Gorham's Vanishing Bone Disease Alliance

Lymphangiomatosis - Gorham's Vanishing Bone Disease

New Resource:

Lymphangiomatosis & Gorham's Vanishing Bone Disease Alliance

The LGD Alliance is a nonprofit foundation dedicated to patient support, advocacy, and effective treatments and cures for those affected by the rare lymphatic malformations known as lymphangiomatosis and Gorham's disease.

Thank you for visiting our website. Our goal is to provide relevant and useful information to help you become more knowledgeable about these diseases.

Please visit the website at:

Lymphangiomatosis & Gorham's Vanishing Bone Disease Alliance

If there is a particular subject you are trying to find information about, and you cannot find it, please send us an email and we will do our best to help. Our email address is .

Discussion forums are going to be added as well.


I wanted to share this important new resource and wish the Alliance the utmost success in their endeavors



Monday, October 22, 2007

Antioxidants Suppress Lymphoma and Increase Longevity in Atm-Deficient Mice

Antioxidants Suppress Lymphoma and Increase Longevity in Atm-Deficient Mice

2007 The American Society for Nutrition J. Nutr. 137:229S-232S, January 2007

Ramune Reliene and Robert H. Schiestl*
Departments of Pathology, Environmental Health and Radiation Oncology, Geffen School of Medicine and School of Public Health, University of California, Los Angeles, CA 90095
* To whom correspondence should be addressed. E-mail:

Ataxia telangiectasia (AT), a human hereditary disorder resulting from mutations in the ATM gene, is characterized by a high incidence of lymphoid malignancies, neurodegeneration, immunodeficiency, premature aging, elevated radiosensitivity, and genomic instability. Evidence has been accumulating that ATM-deficient cells are in a continuous state of oxidative stress. A variety of markers of oxidative stress were detected in AT patients as well as Atm-deficient mice, used as an animal model of AT. Since then, it has been proposed that oxidative stress contributes to the clinical phenotype of AT, especially carcinogenesis and neurodegeneration, and several animal studies were conducted to determine whether exogenous antioxidants mitigate the symptoms of AT. Tempol, EUK-189, and N-acetyl cysteine have been tested as chemopreventive antioxidants in Atm-deficient mice. We review these findings, mainly focusing on the effect of N-acetyl cysteine, which is known as a safe and efficient drug and nutritional supplement.

Journal of Nutrition

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